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    房晨婕

     

    姓名:房晨婕

    性別:女

    職稱:教授

    招生院所:澳門新葡官網進入

    招生類型:博士、碩士

    招生專業:藥劑學

    研究方向名稱:納米材料及其生物醫藥的應用基礎研究

    電子信箱:cjfang@ccmu.edu.cn

    個人簡介

    2007年進入澳門新葡官網進入工作。研究領域著重于分子材料、納米材料的生物醫學應用。在國際重要期刊發表多篇研究論文,其中3篇被選為封底文章,1篇被Chem. Rev.引用點評,1篇獲New. J. Chem.年度hot papers提名。主持國家及北京市自然科學基金項目、北京市教委項目及留學回國人員項目。系列研究成果入選北京市自然科學基金“十二五”期間優秀成果。兼任國家基金委和北京市、天津市等多個省市基金委及海外基金項目評審專家。

     

    教育經歷

    2001,南京大學,配位化學國家重點實驗室,博士

     

    工作經歷

    2007至今,澳門新葡官網進入,副教授、教授

    2004~2006,北京大學稀土材料化學及應用國家重點實驗室,博士后

    2002~2003,Nottingham University, K C Wong fellowship

    2001-2002,Johann Wolfgang Goethe-Universit?t Frankfurt amMain,博士后

     

    重要學術論文:

    (1)Ailing Sun, Di Qian, ZhengWang, Yiliang Xu, Haihong Ye,* Chen-Jie Fang,* Chun-Hua Yan, Protective effect of lipoic acid modification on brain dysfunctions of mice induced by mesoporous silica nanoparticles, Chem. Eng. J. , 2021, DOI: 10.1016/j.cej.2021.128957.IF10.652

    (2)Yuqian Jiang, Zheng Wang, Wei Duan, Lingyan Liu,* Mahan Si, Xiaoyuan Chen,* Chen-Jie Fang.* The critical size of gold nanoparticles for overcoming P-gp mediated multidrug resistance, Nanoscale , 2020, 12, 16451-16461. Back cover article. IF6.895

    (3)Xiaomin Zhi, Yuqian Jiang, Linlin Xie, Yanbo Li, Chen-Jie Fang,* Gold nanorods functionalized with cathepsin B targeting peptide and doxorubicin for combinatorial therapy against multidrug resistance, ACS Appl. Bio Mater. , 2019, 2, 5697-5706.

    (4)Linlin Xie, Xiaomin Zhi, Nao Xiao, Chen-Jie Fang,* Chun-Hua Yan, Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities, RSC Adv. , 2018, 8, 26517-26522.

    (5)Rui-Hui Wang, Jie Bai, Jun Deng, Chen-Jie Fang,* Xiaoyuan Chen,* TAT-Modified gold nanoparticle carrier with enhanced anticancer activity and size effect on overcoming multidrug resistance, ACS Appl. Mater. Interfaces , 2017, 9(7), 5828-5837. IF8.758

    (6)Jie Bai, Rui-Hui Wang, Yan Qiao, Aidong Wang, Chen-Jie Fang,* Schiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index, Drug Design, Development and Therapy , 2017, 11, 2227-2237.IF3.216

    (7)Ming Zhou,# Linlin Xie#, Chen-Jie Fang,* Hua Yang, Yan-Jie Wang, Xiao-Yu Zhen, Chun-Hua Yan,* Yuji Wang, Ming Zhao,* Shiqi Peng,* Implications for blood-brain-barrier permeability, in vitro oxidative stress and neurotoxicity potential induced by mesoporous silica nanoparticles: effects of surface modification, RSC Adv. , 2016, 6, 2800-2809.

    (8) Rui Guo, Le-Le Li, Wen-Hua Zhao, Yu-Xi Chen, Xiao-Zhu Wang, Chen-Jie Fang,* Wei Feng,Tian-Lan Zhang, Xiang Ma, Meng Lu, Shi-Qi Peng* and Chun-Hua Yan, The intracellular controlled release from bioresponsive mesoporous silica with folate as both targeting and capping agent, Nanoscale , 2012, 4, 3577–3583. Back cover article. IF6.895

    (9)Wenjing Wang, Chenjie Fang*, Xiaozhu Wang, Yuxi Chen, Yaonan Wang, WeiFeng, Chunhua Yan, Ming Zhao* and Shiqi Peng*, Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy, Nanoscale , 2013, 5, 6249-6253. Back cover article. IF6.895

    承擔重要項目

    21571133,介孔氧化硅引發的氧化應激及其神經化學,國家自然科學基金委,60萬,2015.01-2019.12。

    21171120,穿越血腦屏障、細胞內環境導放藥物的多功納米器件研究,國家自然科學基金委,55萬, 2012.01-2015.12

    KZ201710025024,硫辛酸在介孔氧化硅引起的氧化應激及神經毒性中的保護作用,北京市自然科學基金-北京市教委重點項目,50萬,2015.01-2019.12

    7132020,生物響應的氧化硅納米載體在聯合化療中的應用基礎研究,北京市自然科學基金委,14萬,2013.01-2015.12

    208207具有可控及定點釋放性能的納米運輸器件研究,北京市自然科學基金委,10萬,2008.01-2010.12

    SQKM201210025007,還原電勢響應的控釋系統載體材料及其穿越血腦屏障研究,13萬,2012.01-2014.12

     

    主編或副主編的著作/譯著

    張楓,房晨婕,醫學化學基礎(第2版),中國協和醫科大學出版社,2010年

    重要獎項

    房晨婕,“十二五”期間北京市基金資助項目優秀成果,2017.1

     



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